LigoFlex Capsules

Summary

Rheumatoid arthritis is a chronic autoimmune inflammatory disease that presents as a symmetrical polyarthritis characterised by joint pain, swelling, and stiffness. It can affect any synovial joint in the body, most commonly starting in the small joints of the hands and feet, with the potential to impact every aspect of daily living. High levels of inflammation are associated with fatigue and impairment of participation in occupational, recreational, and societal roles. Rheumatoid arthritis can affect men, women, and children at any age, but is 2–3 times more likely to occur in women and is more common with increasing age, with onset most often occurring at 60–70 years of age. Without adequate treatment, the disease can lead to progressive joint destruction and deformity, causing long-term disability, chronic pain, and premature death. (Reference: Global, regional, and national burden of rheumatoid arthritis, 1990–2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021; GBD 2021 Rheumatoid Arthritis Collaborators* )

Ingredients

  • Guggulu
  • Withania somnifera
  • Shallaki
  • Haridra
  • Glucosamine HCL

$26.00

Product Details

Description

A natural combination of bioceutical (plant bioactives) COX-2 inhibitor formulation that blocks the action of COX-2 enzymes, which help reduce inflammation and pain. Promotes analgesic anti-inflammatory activities that reduce joint discomfort, increase knee flexion and mobility associated rheumatoid /osteo-arthritic conditions.
LigoFlex Capsule, a drug-free joint health dietary supplement that reduces inflammation, muscle aches and joint pain

Research And Publications

Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study

R R Kulkarni 1, P S Patki, V P Jog, S G Gandage, B Patwardhan
Affiliations Expand
PMID: 1943180 DOI: 10.1016/0378-8741(91)90167-c
Abstract:
The clinical efficacy of a herbomineral formulation containing roots of Withania somnifera, the stem of Boswellia serrata, rhizomes of Curcuma longa and a zinc complex (Articulin-F), was evaluated in a randomized, double-blind, placebo controlled, cross-over study in patients with osteoarthritis. After a one-month single blind run-in period, 42 patients with osteoarthritis were randomly allocated to receive either a drug treatment or a matching placebo for a period of three months. After a 15-day wash-out period the patients were transferred to the other treatment for a further period of three months. Clinical efficacy was evaluated every fortnight on the basis of severity of pain, morning stiffness, Ritchie articular index, joint score, disability score and grip strength. Other parameters like erythrocyte sedimentation rate and radiological examination were carried out on a monthly basis. Treatment with the herbomineral formulation produced a significant drop in severity of pain (P less than 0.001) and disability score (P less than 0.05). Radiological assessment, however, did not show any significant changes in both the groups. Side effects observed with this formulation did not necessitate withdrawal of treatment.

Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial

N Kimmatkar 1, V Thawani, L Hingorani, R Khiyani
Affiliations Expand
PMID: 12622457 DOI: 10.1078/094471103321648593
Abstract:
Osteoarthritis is a common, chronic, progressive, skeletal, degenerative disorder, which commonly affects the knee joint. Boswellia serrata tree is commonly found in India. The therapeutic value of its gum (guggulu) has been known. It posses good anti-inflammatory, anti-arthritic and analgesic activity. A randomized double blind placebo controlled crossover study was conducted to assess the efficacy, safety and tolerability of Boswellia serrata Extract (BSE) in 30 patients of osteoarthritis of knee, 15 each receiving active drug or placebo for eight weeks. After the first intervention, washout was given and then the groups were crossed over to receive the opposite intervention for eight weeks. All patients receiving drug treatment reported decrease in knee pain, increased knee flexion and increased walking distance. The frequency of swelling in the knee joint was decreased. Radiologically there was no change. The observed differences between drug treated and placebo being statistically significant, are clinically relevant. BSE was well tolerated by the subjects except for minor gastrointestinal ADRs. BSE is recommended in the patients of osteoarthritis of the knee with possible therapeutic use in other arthritis
Abstract:
Withania somnifera, commonly known as "Ashwagandha" or "Indian ginseng" is an essential therapeutic plant of Indian subcontinent regions. It is regularly used, alone or in combination with other plants for the treatment of various illnesses in Indian Systems of Medicine over the period of 3,000 years. Ashwagandha (W. somnifera) belongs to the genus Withania and family Solanaceae. It comprises a broad spectrum of phytochemicals having wide range of biological effects. W. somnifera has demonstrated various biological actions such as anti-cancer, anti-inflammatory, anti-diabetic, anti-microbial, anti-arthritic, anti-stress/adaptogenic, neuro-protective, cardio-protective, hepato-protective, immunomodulatory properties. Furthermore, W. somnifera has revealed the capability to decrease reactive oxygen species and inflammation, modulation of mitochondrial function, apoptosis regulation and improve endothelial function. Withaferin-A is an important phytoconstituents of W. somnifera belonging to the category of with anolides been used in the traditional system of medicine for the treatment of various disorders. In this review, we have summarized the active phytoconstituents, pharmacologic activities (preclinical and clinical), mechanisms of action, potential beneficial applications, marketed formulations and safety and toxicity profile of W. somnifera. (Reference: Deepa S Mandlik Ingawale, Ajay G Namdeo).

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